Two very short examples to get you started, which send and receive “pure” binary = very little bandwidth, with a persistent connection.

Here are two send-receive samples which should allow you to do all your binary sendings:

1. C#: the client sends a byte, which corresponds to a boolean, to say if it is in big or little endian;
2. C#: the client sends a message encoded in UTF-8 (yes I found the solution that works!);
3. Python: the server reads this boolean;
4. Python: the server reads the message and says it (under Windows only, remove the code if you’re under Linux);
5. Python: the server sends an unsigned integer, then two floats;
6. C#: the client reads the unsigned integer then two floats.

With that, you have enough to understand and make all the streams you want!

Asynchronous TCP Python server

import asyncio
import struct
from asyncio import StreamWriter, StreamReader
import pythoncom
import win32com.client as win32_client
HOST = '192.168.1.31'
PORT = 9696
async def handle(reader: StreamReader, writer: StreamWriter):
    is_little_endian = False
    buffer = bytearray(100)
    addr = writer.get_extra_info('peername')
    print(f"Connected with {addr!r}")
    is_little_endian, = struct.unpack_from(
        '?', await reader.read(struct.calcsize('c'))
    )
    print(f'{is_little_endian=}')
    data = await reader.read(4096)
    message = data.decode('utf8')
    pythoncom.CoInitialize()
    speak = win32_client.Dispatch('SAPI.SpVoice')
    speak.Speak(message)
    print(f"Received {message!r} from {addr!r}")
    print(f"Send: {message!r}")
    float1 = 1.1
    float2 = 2.2
    struct.pack_into(
        # =: native order, std. size & alignment
        # H: unsigned short
        # f: float
        "=Hff",
        buffer, 0, 1, float1, float2)
    writer.write(buffer)
    await writer.drain()
    print("Close the connection")
    writer.close()
async def main():
    server = await asyncio.start_server(handle, HOST, PORT)
    print(f'Serving on {server.sockets[0].getsockname()}')
    async with server:
        await server.serve_forever()
asyncio.run(main())

C# Unity Client

using System;
using System.IO;
using System.Net.Sockets;
using UnityEngine;
public class Connexion : MonoBehaviour
{
    public string server;
    public string message;
    public ushort port;
    private void Start()
    {
        // working sample to send text:
        byte[] data = System.Text.Encoding.UTF8.GetBytes(message);
        byte isLittleEndian = BitConverter.IsLittleEndian ? (byte)1 : (byte)0;
        TcpClient client = new TcpClient(server, port);
        NetworkStream stream = client.GetStream();
        // Send the message to the connected TcpServer.
        stream.WriteByte(isLittleEndian);
        stream.Write(data, 0, data.Length);
        Debug.Log($"Sent: {message}");
        // read sample
        BinaryReader reader = new BinaryReader(stream);
        uint len = reader.ReadUInt16();
        var x = reader.ReadSingle();
        var y = reader.ReadSingle();
        Debug.Log("len=" + len);
        Debug.Log($"x={x}, y={y}");
    }
}


For the record, these two examples seem simple, but they took me a long time, and I had no answer after 3 weeks on stackoverflow…